Monoamine oxidase A regulates neural differentiation of murine embryonic stem cells

J Neural Transm (Vienna). 2011 Jul;118(7):997-1001. doi: 10.1007/s00702-011-0655-0. Epub 2011 May 24.

Abstract

Monoamine oxidase (MAO) A is the major metabolizing enzyme of serotonin (5-hydroxytryptamine, 5-HT) which regulates early brain development. In this study, wild-type (WT) and MAO A(neo) embryonic stem (ES) cell lines were established from the inner cell mass of murine blastocysts and their characteristics during ES and differentiating stages were studied. Our results show that the differentiation to neural cells in MAO A(neo) ES cells was reduced compared to WT, suggesting MAO A played a regulatory role in stem cells neural differentiation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Differentiation / physiology*
  • Cell Line
  • Embryonic Stem Cells / cytology
  • Embryonic Stem Cells / enzymology*
  • Female
  • Male
  • Mice
  • Mice, Transgenic
  • Monoamine Oxidase / genetics*
  • Monoamine Oxidase / metabolism*
  • Neural Stem Cells / cytology
  • Neural Stem Cells / enzymology*
  • Neurogenesis / physiology*
  • Neurons / cytology
  • Neurons / enzymology*
  • Pregnancy

Substances

  • Monoamine Oxidase