User profiles for clay wang
 | clay wangProfessor of Pharmaceutical Sciences, USC Verified email at usc.edu Cited by 40446 |
Chromatin-level regulation of biosynthetic gene clusters
Loss-of-function Aspergillus nidulans CclA, a Bre2 ortholog involved in histone H3 lysine 4
methylation, activated the expression of cryptic secondary metabolite clusters in A. nidulans. …
methylation, activated the expression of cryptic secondary metabolite clusters in A. nidulans. …
A Gene Cluster Containing Two Fungal Polyketide Synthases Encodes the Biosynthetic Pathway for a Polyketide, Asperfuranone, in Aspergillus nidulans
The genome sequencing of Aspergillus species including A. nidulans reveals that the products
of many of the secondary metabolism pathways in these fungi have not been elucidated. …
of many of the secondary metabolism pathways in these fungi have not been elucidated. …
Advances in Aspergillus secondary metabolite research in the post-genomic era
Covering: 2005 to 2011 This review studies the impact of whole genome sequencing on
Aspergillus secondary metabolite research. There has been a proliferation of many new, …
Aspergillus secondary metabolite research. There has been a proliferation of many new, …
Two Separate Gene Clusters Encode the Biosynthetic Pathway for the Meroterpenoids Austinol and Dehydroaustinol in Aspergillus nidulans
Meroterpenoids are a class of fungal natural products that are produced from polyketide and
terpenoid precursors. An understanding of meroterpenoid biosynthesis at the genetic level …
terpenoid precursors. An understanding of meroterpenoid biosynthesis at the genetic level …
Total biosynthesis of antitumor nonribosomal peptides in Escherichia coli
Nonribosomal peptides (NRPs) are a class of microbial secondary metabolites that have a
wide variety of medicinally important biological activities, such as antibiotic (vancomycin), …
wide variety of medicinally important biological activities, such as antibiotic (vancomycin), …
Recent advances in awakening silent biosynthetic gene clusters and linking orphan clusters to natural products in microorganisms
Secondary metabolites from microorganisms have a broad spectrum of applications, particularly
in therapeutics. The growing number of sequenced microbial genomes has revealed a …
in therapeutics. The growing number of sequenced microbial genomes has revealed a …
An efficient system for heterologous expression of secondary metabolite genes in Aspergillus nidulans
…, SL Chang, CT Sung, CCC Wang… - Journal of the …, 2013 - ACS Publications
Fungal secondary metabolites (SMs) are an important source of medically valuable compounds.
Genome projects have revealed that fungi have many SM biosynthetic gene clusters …
Genome projects have revealed that fungi have many SM biosynthetic gene clusters …
Plumbagin induces cell cycle arrest and apoptosis through reactive oxygen species/c-Jun N-terminal kinase pathways in human melanoma A375. S2 cells
This study is the first to investigate the anticancer effect of plumbagin in human melanoma
A375.S2 cells. Plumbagin exhibited effective cell growth inhibition by inducing cancer cells to …
A375.S2 cells. Plumbagin exhibited effective cell growth inhibition by inducing cancer cells to …
[PDF][PDF] Molecular genetic mining of the Aspergillus secondary metabolome: discovery of the emericellamide biosynthetic pathway
The recently sequenced genomes of several Aspergillus species have revealed that these
organisms have the potential to produce a surprisingly large range of natural products, many …
organisms have the potential to produce a surprisingly large range of natural products, many …
Prototype of an intertwined secondary-metabolite supercluster
The hallmark trait of fungal secondary-metabolite gene clusters is well established, consisting
of contiguous enzymatic and often regulatory gene(s) devoted to the production of a …
of contiguous enzymatic and often regulatory gene(s) devoted to the production of a …