80 CADENAS monplace in aerobically metabolizing cells. The stability of a variety of reactive
O2 intermediates, whether of free radical character or not, differs substantially, but in some …

Mitochondria have been described as “the powerhouses of the cell” because they link the
energy-releasing activities of electron transport and proton pumping with the energy …

Mitochondria were classically recognized as the organelles that produce the energy required
to drive the endergonic processes of cell life, but now they are considered as the most …

Antimycin-inhibited bovine heart submitochondrial particles generate O2- and H2O2 with
succinate as electron donor. H2O2 generation involves the action of the mitochondrial …

Oxidative cell damage can be monitored by detection of (a) photoemission of singlet molecular
oxygen formed from radical interactions (so-called low-chemical chemiluminescence), (b) …

It has been generally accepted that superoxide anion generated by the mitochondrial
respiratory transport chain are vectorially released into the mitochondrial matrix, where they are …

A synthetic seleno-organic compound, 2-phenyl-1,2-benzoisoselenazol-3(2H)-one (PZ 51),
exhibits GSH peroxidase-like activity in vitro, in contrast to its sulfur analog, PZ 25. In addition…

Complex I (NADH-ubiquinone reductase) and Complex III (ubiquinol-cytochrome c
reductase) supplemented with NADH generated O 2 − at maximum rates of 9.8 and 6.5 nmol/min/mg …

Several reactions in biological systems contribute to maintain the steady-state concentrations
of superoxide anion (O 2 ⨪ ) and hydrogen peroxide (H 2 O 2 ). The electron transfer chain …

The Handbook of Antioxidants: Second Edition, Revised and Expanded, is an authoritative
treatise on the chemical, biological, and clinical aspects of antioxidant molecules. Each …